Herpes virus link to bipolar disorder and depression

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Findings provide evidence to support the role of human roseoloviruses, HHV-6A, and HHV-6B in bipolar disorder and major depressive disorder.

Purkinje cells are a central part of the human cerebellum, the part of the brain that plays an important role in motor learning, fine motor control of the muscle, equilibrium, and posture but also influences emotions, perception, memory and language.

Scientists from the Institute for Virology and Immunobiology of the University of Wrzburg and their US colleagues have now made a surprising discovery in these nerve cells. They found a high infection rate of Purkinje neurons with the human herpes virus HHV-6 for the first time in patients with two types of psychiatric disorders: bipolar disorder and/or severe depression. The study was led by Dr. Bhupesh Prusty, group leader at the Department of Microbiology. The scientists published the results of their study inFrontiers in Microbiology.

Virus-related inflammation in the brain

Inherited factors have long been known to increase the risk of developing several types of psychiatric disorders including bipolar disorder, major depressive disorder, and schizophrenia, Prusty explains.

But there is also strong evidence that environmental factors, particularly those that lead to neuroinflammation early in life, might play an important etiologic role in the pathogenesis of these disorders as well. Viruses are such an environmental factor.

Pathogens may disrupt neurodevelopment and cross-talk with the immune system at key developmental stages, Prusty explains. Children that are infected at a young age usually recover without any late complications. However, the viruses lie dormant (latent) in various organs and tissues including the central nervous system and the salivary glands and can be reactivated under certain circumstances, even after years.

Increased infection rate in two psychiatric disorders

Prusty and his team suspected the human herpesviruses HHV-6A and HHV-6B to play a key role in the genesis of psychiatric disorders. So they studied two of the largest human brain biopsy cohorts from Stanley Medical Research Institute (USA) and what they found confirmed their assumption.

Researchers show for the first time that type HHV-6 viruses are capable of infecting neurons and possibly causing cognitive disturbances leading to psychiatric disorders. The image is credited to University of Wrzburg.

We were able to find active infection of HHV-6 predominantly within Purkinje cells of human cerebellum in bipolar and major depressive disorder patients, Prusty sums up the central result of their study. The results show for the first time that type HHV-6 viruses are capable of infecting neurons and possibly causing cognitive disturbances leading to mood disorder.

According to the scientists, the study disproves the belief that viruses which lie dormant and hidden in organs and tissues never cause any disease. Studies like ours prove this thinking as wrong, Prusty says and he cites another study which shows that Alzheimers disease can also be caused by human herpesvirus 6A.

In the next step, the Wrzburg researchers want to figure out the molecular mechanisms behind HHV-6A mediated cellular damage to Purkinje neurons.

Source: Frontiers /https://neurosciencenews.com